Hydroxyamine hydrochloride → HCID 85438995, compound

Participants

Reaction Steps

A mixture of 11.2 g. (28 mmol) of the final product of Example 3, 5.80 g. (84 mmol) of hydroxylamine hydrochloride and 180 ml. pyridine was heated to reflux for 6.5 hours. After cooling to room temperature, the reaction was concentrated in vacuo to remove the pyridine. The crude product, as isolated, was then chromatographed on silica gel, using 10% EtOAc in benzene as eluent, to give the final product. Recrystallization from EtOH/H2O gave an analytical sample as colorless prisms mp: 177°-179°.

Provenance & Evidence