Hydrochloric Acid → HCID 46214482, compound

Participants

Reaction Conditions

Reaction Steps

In a 100 mL flask under argon was dissolved N-[6-(2-amino-6-methyl-4-pyrimidinyl)-1H-indazol-3-yl]acetamide (0.021 g, 0.074 mmol) in CH3OH (5 mL). HCl (2.26 μl, 0.074 mmol) was added and the solution was stirred for 8 hours at 60° C. The reaction was cooled to room temperature. The resulting precipitate was filtered and washed with minimal CH3OH to afford an HCl salt of the title compound (6 mg, 26%) as a white solid. LC-MS (ES) m/z=241 [M+H]+. 1H NMR (400 MHz, DMSO-d6): δ 2.51 (s, 3H {assumed to be hidden beneath DMSO peak}), 7.59 (s, 1H), 7.81 (dd, J=8.6, 1.3 Hz, 1H), 7.99 (d, J=8.6 Hz, 1H), 8.21 (s, 1H), 12.72 (bs, 1H).

Provenance & Evidence