HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-chloropyrimidine → HCID 58504552, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-chloropyrimidine | HCID 223332 | — |
| Reactant | 3,5-Difluoro-4-formylphenylboronic acid | HCID 16217708 | — |
| Product | HCID 58504552 | HCID 58504552 | 91.3% |
Reaction Steps
The title compound was prepared following the General Procedure A using: (3,5-difluoro-4-formylphenyl)boronic acid (4.93 g, 26.5 mmol) and 4-chloro-2-pyrimidinamine (3.44 g, 26.5 mmol). Flash chromatography on SiO2 (gradient: 100% CHCl3 to 10% THF/90% CHCl3) afforded the title compound (5.69 g, 75%) as an off-white solid. LC-MS (ES) m/z=236 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697685B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-f9461ab8fb8044178dabbe0eb8e80936 |
| Source note | uspto-grants-2014_04 |