Sodium Sulfite → HCID 86659171, compound

Participants

Reaction Steps

To cis-1-[6-chloro-2-(methylthio)-4-pyrimidinyl]-N-cyclohexyl-6-(trifluoromethyl)-3-piperidinecarboxamide (590 mg, 1.350 mmol) in CH2Cl2 (12 mL) was added mCPBA (757 mg, 3.38 mmol), and the reaction mixture was stirred for 1 hour at room temperature. A saturated solution of Na2SO3 was added, and the resulting mixture was stirred for 30 minutes. The mixture was poured onto saturated aqueous NaHCO3 and EtOAc. The organic layer was separated, washed with brine, dried (MgSO4), filtered and concentrated to afford the title compound (640 mg) as a white solid. LC-MS (ES) m/z=469, 471 [M+H]+.

Provenance & Evidence