Diisopropylethylamine → HCID 66991412, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-[2-amino-6-(methylsulfonyl)-4-pyrimidinyl]-1H-indazol-3-amine (500 mg, 1.64 mmol), 2-(2-fluorophenyl)ethanamine (500 mg, 2.19 mmol), and Hunig's base (2 mL) in NMP (3 mL) was heated for 4 hours at 140° C. in a BiotageInitiator® microwave synthesizer. Upon cooling, the mixture was decanted to remove the solids, and the resulting solution was concentrated to dryness. The crude material was purified by RPHPLC (gradient: 20% CH3CN/H2O to 40% CH3CN/H2O) to afford the title compound (166 mg) as a yellow solid. LC-MS (ES) m/z=364 [M+H]+. 1H NMR (400 MHz, DMSO-d6): δ 2.86-2.90 (m, 2H), 3.49-3.51 (m, 2H), 5.35 (s, 2H), 5.98 (s, 2H), 6.25 (s, 1H), 6.97 (s, 1H), 7.12-7.17 (m, 2H), 7.23-7.29 (m, 1H), 7.33-7.41 (m, 2H), 7.68 (d, J=8.4 Hz, 1H), 7.82 (s, 1H), 11.50 (s, 1H).

Provenance & Evidence