2-Amino-4,6-dichloropyrimidine → HCID 51353725, compound

Participants

Reaction Conditions

Reaction Steps

In a 2-5 mL microwave vessel Hunig's base (0.59 mL, 3.35 mmol) was added to [(2S,5R)-5-methyl-2-morpholinyl]methanol hydrochloride (208 mg, 1.12 mmol) in CH3CN (3 mL), and then 2-amino-4,6-dichloropyrimidine (174 mg, 1.06 mmol) was added. The mixture was heated with stirring in a microwave reactor at 160° C. for 1 hour. HPLC indicated complete conversion. The mixture was filtered through a 0.45 um filter disc, evaporated, and the product was purified further by chomatography (Analogix SF25-40 g silica column) eluting with 2-5% CH3OH—CHCl3 to afford the title compound (258 mg) as a white foam. LC-MS (ES) m/z=260 [M+H]+.

Provenance & Evidence