Water → 4-Bromo-2,6-difluorobenzonitrile

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 4-bromo-2,6-difluorobenzamide (9 5 g) in DMF (1 L) at 0° C. was added cyanuric chloride (82 g) slowly, and the reaction mixture was stirred at 0° C. for 4 hours. Water (5 L) was added slowly to the reaction, and it was extracted with EtOAc (2 L). The organic layer was separated, dried over MgSO4, filtered and evaporated under vacuum to afford the crude product, which was purified by chromatography (SiO2, 300-400 mesh, petroleum ether:EtOAc=200:1) to provide 47 g of pure title compound and 17 g of impure title compound. 1H NMR (300 MHz, DMSO-d6): δ 7.90 (m, 2H).

Provenance & Evidence