反应详情

温度

50 °C

To a stirred solution of 27 parts of N-[1-(phenylmethyl)-4-piperidinylidene]-3-pyridinamine in 40 parts of ethanol are added portionwise 3.8 parts of sodium borohydride. After the addition is complete, the whole is heated to 50° C. The solvent is evaporated. The oily residue is dissolved in 150 parts of hydrochloric acid 1 N and filtered. The filtrate is rendered alkaline with ammonium hydroxide and extracted with methylbenzene. The organic layer is dried over magnesium sulfate, filtered and evaporated. The solid residue is washed with 2,2'-oxybispropane and dried, yielding 14 parts of N-[1-(phenylmethyl)-4-piperidinyl]-3-pyridinamine; mp. 131°-133° C.; beige, amorphous powder.

1. additionAfter the addition
2. customThe solvent is evaporated
3. dissolutionThe oily residue is dissolved in 150 parts of hydrochloric acid 1 N
4. filtrationfiltered
5. extractionextracted with methylbenzene
6. dry with materialThe organic layer is dried over magnesium sulfate
7. filtrationfiltered
8. customevaporated
9. washThe solid residue is washed with 2,2'-oxybispropane
10. customdried