Triethylamine → HCID 40011628, compound

Participants

Reaction Conditions

Reaction Steps

To (3S)—N-phenyl-3-piperidinecarboxamide (327 mg, 1.6 mmol) in CH3CN (10 mL) was added 4,6-dichloro-2-pyrimidinamine (289 mg, 1.760 mmol) and triethylamine (0.446 mL, 3.20 mmol), and the solution was allowed to stir overnight at 50° C. The reaction was then quenched with water (2 mL), and extracted 3× with EtOAc. The organics were combined, dried (Na2SO4), filtered and concentrated to afford the crude title compound (350 mg) as a solid. LC-MS (ES) m/z=332 [M+H]+.

Provenance & Evidence