3,4-Diaminopyridine → HCID 178420318, compound

Participants

Reaction Steps

A mixture of 3,4-pyridinediamine (1.7 g, 15.58 mmol), 4-benzylmorpholine-2-carboxylic acid hydrochloride (4.82 g, 18.69 mmol) and polyphosphoric acid (40 mL, 15.58 mmol) was refluxed for 12 hours. Then water (70 mL) and NH4OH were added thereto, and the resulting mixture was extracted with CH2Cl2 (10% CH3OH) (3×80 mL). The combined organic solution was washed with brine (2×100 mL), dried, and evaporated in vacuo to afford the title compound (1.0 g). LC-MS (ES) m/z=295 [M+H]+.

Provenance & Evidence