2-Amino-4,6-dichloropyrimidine → HCID 178508442, compound

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Reaction Steps

a solution of 2-(2-morpholinyl)-1H-imidazo[4,5-c]pyridine (0.996 g, 4.88 mmol), 4,6-dichloro-2-pyrimidinamine (0.8 g, 4.88 mmol) and Hunig's base (2.12 mL, 12.2 mmol) in ethanol (24.39 mL) was heated at 85° C. overnight. The mixture was concentrated and chromatographed (PE-EtOAc, 1:5) to afford the title compound (0.9 g). LC-MS (ES) m/z=332 [M+H]+.

Provenance & Evidence