Sodium Hydroxide → HCID 178488060, compound

Participants

Reaction Steps

A solution of 4-methoxybenzene-1,2-diamine (0.5 g, 2.369 mmol) and 4-(phenylmethyl)-2-morpholinecarboxylic acid (1.221 g, 4.74 mmol) in 6N HCl (10 mL) was stirred at 105° C. overnight. The reaction mixture was neutralized with aqueous NaOH and partitioned between EtOAc (50 mL) and water (50 mL). The organic phase was washed with water (50 mL), dried (MgSO4), and evaporated in vacuo to give the crude product as a black oil. The crude product was added to a silica gel column and was eluted with 90:10 CH2Cl2/CH3OH to afford the title compound (0.6 g). LC-MS (ES) m/z=324 [M+H]+.

Provenance & Evidence