反应详情

To a warm solution of 192 parts of ethyl 4-[(4-chlorophenyl)imino]-1-piperidinecarboxylate in 560 parts of methanol is added portionwise 23.5 parts of sodium borohydride at 50° C. and over a period of one hour. After the addition is complete, the mixture is stirred at the same temperature for 2 hours. The methanol is evaporated. The solid residue is heated with ±600 parts of water and the product is extracted with benzene. The extract is dried over magnesium sulfate and evaporated. The oily residue solidifies on treating with 2,2'-oxybispropane. The solid is filtered off and dried, yielding 122 parts of ethyl 4-[(4-chlorophenyl)amino]-1-piperidinecarboxylate; mp. 115°-118° C.

1. additionAfter the addition
2. customThe methanol is evaporated
3. temperatureThe solid residue is heated with ±600 parts of water
4. extractionthe product is extracted with benzene
5. dry with materialThe extract is dried over magnesium sulfate
6. customevaporated
7. additionon treating with 2,2'-oxybispropane
8. filtrationThe solid is filtered off
9. customdried