Hydrochloric Acid → HCID 178488061, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(methyloxy)-2-[4-(phenylmethyl)-2-morpholinyl]-1H-benzimidazole (2.0 g, 6.18 mmol), and hydrogen chloride (0.451 g, 12.37 mmol) in CH3OH (50 mL) stirred under nitrogen at room temperature was added palladium on carbon (0.066 g, 0.618 mmol). The reaction mixture was stirred under hydrogen at 25° C. for 3 hours. CH2Cl2 was added and the mixture was filtered. The filtrate was concentrated in vacuo. The crude product was added to a silica gel column and was eluted with 90:10 CH2Cl2/CH3OH to afford the title compound (500 mg). LC-MS (ES) m/z=234 [M+H]+.

Provenance & Evidence