Hydrochloric Acid → HCID 178477902, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-benzyl-2-(5-chloro-1H-benzo[d]imidazol-2-yl)morpholine (2.1 g, 6.41 mmol), and hydrogen chloride (0.234 g, 6.41 mmol) in CH3OH (50 mL) stirred under nitrogen at room temperature was added palladium on carbon (0.068 g, 0.641 mmol). The reaction mixture was stirred under hydrogen at 25° C. for 3 hours. CH2Cl2 was added and the mixture was filtered. The filtrate was evaporated in vacuo and the residue was dissolved in water (10 mL). The crude product was purified via reverse phase chromatography, eluting with 5˜50% of CH3OH in water, to afford the title compound (400 mg) as a white solid. LC-MS (ES) m/z=238 [M+H]+.

Provenance & Evidence