2-Amino-4,6-dichloropyrimidine → HCID 178508440, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-chloro-2-(2-morpholinyl)-1H-benzimidazole (200 mg, 0.841 mmol) and Hunig's base (109 mg, 0.841 mmol) in ethanol (10 mL) stirred at room temperature was added 4,6-dichloro-2-pyrimidinamine (138 mg, 0.841 mmol), and the reaction mixture was stirred overnight at 85° C. The reaction mixture was cooled to room temperature and partitioned between EtOAc (25 mL) and water (25 mL). The solvent was evaporated in vacuo to give the crude product. The residue was triturated with EtOAc (1×5 mL). The resulting solid was filtered, and collected to afford the title compound (300 mg). LC-MS (ES) m/z=365, 367 [M+H]+.

Provenance & Evidence