Sodium Hydroxide → HCID 178505465, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-fluorobenzene-1,2-diamine (2.0 g, 15.86 mmol) and 4-benzylmorpholine-2-carboxylic acid (5.26 g, 23.78 mmol) in polyphosphoric acid (20 mL) was stirred at 140° C. overnight. The reaction mixture was cooled to room temperature and treated with 100 mL of water. The aqueous phase was adjusted to weakly basic with 2 N aqueous sodium hydroxide and extracted with EtOAc. The organic phase was dried over MgSO4 and evaporated in vacuo to give the crude product as a red solid. The residue was triturated with Hexanes/EtOAc (1×25 mL). The resulting solid was filtered, rinsed with n-hexane, and collected. The solvent was evaporated in vacuo to afford the title compound (3.0 g). LC-MS (ES) m/z=312 [M+H]+.

Provenance & Evidence