Hydrochloric Acid → HCID 178505466, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-fluoro-2-[4-(phenylmethyl)-2-morpholinyl]-1H-benzimidazole (3.0 g, 9.64 mmol), and hydrogen chloride (0.703 g, 19.27 mmol) in CH3OH (50 mL) stirred under nitrogen at room temperature was added palladium on carbon (0.103 g, 0.964 mmol), and the reaction mixture was stirred under hydrogen at 25° C. overnight. CH2Cl2 was added and the mixture was filtered. The filtrate was concentrated in vacuo and the residue was triturated with EtOAc, filtered and dried to afford a hydrochloride salt of the title compound as a off-white solid (2.0 g). LC-MS (ES) m/z=222 [M+H]+.

Provenance & Evidence