Hydrochloric Acid → HCID 86659192, compound

Participants

Reaction Steps

A suspension of cis-1-[6-chloro-2-(methylthio)-4-pyrimidinyl]-6-(trifluoromethyl)-3-piperidinecarboxylic acid (180 mg, 0.506 mmol) in CH3OH (8 mL) and water (2.5 mL) was cooled in an ice bath and treated slowly with a premixed solution of oxone (778 mg, 1.27 mmol) in water (3 mL). The reaction was stirred at room temperature overnight. The pH was adjusted pH to acidic with 1N HCl and then 5 mL of water was added. The resulting mixture was filtered over fritted funnel to isolate the title compound (79 mg) as a white solid. LC-MS (ES) m/z=388, 390 [M+H]+.

Provenance & Evidence