Methanol → HCID 58504729, compound

Participants

Reaction Steps

A suspension of cis-1-[6-chloro-2-(methylthio)-4-pyrimidinyl]-N-(phenylmethyl)-6-(trifluoromethyl)-3-piperidinecarboxamide (550 mg, 1.236 mmol) in CH3OH (5 mL) and water (1.5 mL) was cooled in an ice bath and treated slowly with a premixed solution of oxone (2280 mg, 3.71 mmol) in water (0.5 mL). The reaction was stirred at room temperature over the weekend. Water (10 mL) was added and the resulting mixture was filtered. The solid was dried in vacuum oven at 35° C. overnight to afford the crude title compound (834 mg) as an off-white solid. LC-MS (ES) m/z=477 [M+H]+.

Provenance & Evidence