Ammonium trifluoroacetate → HCID 178478014, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-[2-(2-chlorophenyl)-2-oxoethyl]-4-(phenylmethyl)-2-morpholinecarboxamide (350 mg, 0.939 mmol) and ammonium trifluoroacetate (615 mg, 4.69 mmol) was heated at 150° C. for 1.5 hours. Water (150 mL) was added to the residue, and the mixture was extracted with EtOAc (3×100 mL). The combined organics were dried with anhydrous Na2SO4, filtered and concentrated to afford the title compound (320 mg) as a brown solid. LC-MS (ES) m/z=354 [M+H]+.

Provenance & Evidence