Hydrochloric Acid → HCID 178478015, compound

Participants

Reaction Conditions

Reaction Steps

Palladium on carbon (10 wt %, 96 mg, 0.090 mmol) was added to a solution of 2-[4-(2-chlorophenyl)-1H-imidazol-2-yl]-4-(phenylmethyl)morpholine (320 mg, 0.904 mmol) and hydrochloric acid (36%, 0.382 mL, 4.52 mmol) in CH3OH (80 mL) under nitrogen, and the mixture was stirred under hydrogen at 25° C. for 1.5 hours. The reaction mixture was filtered, washed by CH3OH (150 mL), and concentrated to afford the title compound (250 mg) as a brown solid. LC-MS (ES) m/z=264 [M+H]+.

Provenance & Evidence