Diisopropylethylamine → HCID 58504678, compound

Participants

Reaction Conditions

Reaction Steps

4,6-Dichloro-N-methyl-2-pyrimidinamine (0.143 g, 0.805 mmol) was added to a 20 mL microwave vial followed by the addition of (2S,5R)-5-ethyl-N-(phenylmethyl)-2-morpholinecarboxamide (0.200 g, 0.805 mmol) in CH3CN (5 mL) and Hunig's base (0.703 mL, 4.03 mmol). The reaction was irradiated at 150° C. for 10 minutes. The reaction was left in the 20 mL sealed microwave vessel and heated to 100° C. over the weekend. The reaction mixture was diluted with water and extracted with EtOAc (2×). The organic layers were combined and dried to afford the title compound (0.805 g) as an oil. LC-MS (ES) m/z=376 [M+H]+.

Provenance & Evidence