Diisopropylethylamine → HCID 58504396, compound

Participants

Reaction Conditions

Reaction Steps

(3R)-3-Ethylmorpholine (5 g, 43.4 mmol) was taken up in CH3CN (100 mL) and Hunig's base (15.2 mL, 87 mmol), followed by the addition of 4,6-dichloro-N-methyl-2-pyrimidinamine (6.96 g, 39.1 mmol), and the reaction was heated to 130° C. overnight in a sealed tube. The reaction mixture was concentrated and then purified via flash chromatography (0-15% EtOAc/CHCl3, 400 g). Fractions were combined and concentrated to afford the title compound (1.6 g) as a colorless oil. LC-MS (ES) m/z=257 [M+H]+.

Provenance & Evidence