Sodium → HCID 58504597, compound

Participants

Reaction Steps

A solution of sodium methoxide was made from 65 mg of sodium dissolved in 2.8 mL of CH3OH. From that solution 0.4 mL was added to a predissolved solution of 2,6-difluoro-4-{2-(methylamino)-6-[(2S)-2-(trifluoromethyl)-1-pyrrolidinyl]-4-pyrimidinyl}benzonitrile (127 mg, 0.331 mmol) in CH3OH (3 mL). The reaction was stirred at room temperature overnight. The reaction was concentrated, then diluted with water (15 mL) and extracted with EtOAc (3×15 mL). The organic was combined, dried over MgSO4, filtered and concentrated to afford the crude title compound (131 mg). LC-MS (ES) m/z=396 [M+H]+.

Provenance & Evidence