Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To 1,1-dimethylethyl{(3R,5R)-1-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}carbamate (127 mg, 0.298 mmol) in 1,4-dioxane (4 mL) was added 4M HCl in 1,4-dioxane (0.074 mL, 0.298 mmol), and the reaction was allowed to stir at room temperature for 3 hours. The reaction was concentrated to afford the bis HCl salt of the title compound (164 mg) as an off-white solid. LC-MS (ES) m/z=327 [M+H]+.

Provenance & Evidence