Water → HCID 58504497, compound

Participants

Reaction Steps

To a solution of 4-[6-[(2R)-2-ethyl-1-pyrrolidinyl]-2-(methylamino)-4-pyrimidinyl]-2,6-difluorobenzonitrile (140 mg, 0.408 mmol) in DMF (4 mL), was added methyl mercaptan sodium salt (ca. 15% in water) (252 mg, 0.543 mmol). The orange colored solution was stirred at room temperature overnight in a capped 10 mL vial. LCMS was very clean. The mixture was poured into water (15 mL). The formed solid was filtered, washed by water and dried to afford the title compound (136 mg) as a light yellow solid. LC-MS (ES) m/z=372 [M+H]+.

Provenance & Evidence