HCID 51354610, compound → HCID 51354611, compound

Participants

Reaction Steps

Into a Parr shaker jar was added Pd/C Deguessa type (0.922 g, 0.433 mmol) followed by a solution of 1,1-dimethylethyl methyl[(3R,5R)-5-methyl-1-(phenylmethyl)-3-piperidinyl]carbamate (1.38 g, 4.33 mmol) in Ethanol (20 mL). The Parr shaker jar was then placed on to the Parr Shaker machine and flushed the jar with N2 then pressurized the jar with hydrogen to 30 psi. The reaction was let shake at room temperature overnight. The reaction was filtered and concentrated to isolate 860 mg of crude product as a clear oil, which was used without purification. LC-MS (ES) m/z=229 [M+H]+.

Provenance & Evidence