Dimethylamine → HCID 66823272, compound

HRID 2367657Notes

Reaction equation

HRID 2367657 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N+:10]([O-:12])=[O:11])[C:5]#[N:6].[CH3:13][NH:14][CH3:15]>C(O)C>[CH3:13][N:14]([CH3:15])[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N+:10]([O-:12])=[O:11])[C:5]#[N:6]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 27833993-Fluoro-4-nitrobenzonitrile

Product 1

HCID 66823272HCID 66823272, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The mixture of 16.7 g (100 mmol) of 3-fluoro-4-nitrobenzonitrile and 100 mL of the solution of dimethylamine in ethanol (5 M) was refluxed overnight. The resulting dark red solution was then poured in to 100 mL of ice-water. The precipitate was collected by filtration and washed by H2O (50 mL×2) and ethanol (50 mL×2) to give 16.9 g of a organe needle crystal as the desired product. MS ESI (m/z) 192 (M+1)+.

Workup

  1. temperaturewas refluxed overnight
  2. filtrationThe precipitate was collected by filtration
  3. washwashed by H2O (50 mL×2) and ethanol (50 mL×2)

Sources & evidence

ORD record
ord-55dbaea57a1d4cadac56be1e635cc3e3
Source dataset
uspto-grants-2014_04
Patent number
US08697875B2

Reaction notes

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