Hydrochloric Acid → HCID 86667230, compound

Participants

Reaction Steps

To a solution of [3-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-ylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester (3.56 g, 8.76 mmol) in anhydrous DCM (175 mL) at rt add HCl (44 mL 4M solution in 1,4-dioxane, 175 mmol) and stir the reaction at rt for 24 h. Dilute the solid suspension with Et2O (300 mL) and hexane (500 mL), stir vigorously for 20 min Filter and wash with Et2O and hexane to afford the desired product 3-aminomethyl-N-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-benzamide dihydrochloride as a solid (3.28 g, 8.64 mmol).

Provenance & Evidence