Hydrochloric Acid → HCID 86667232, compound

Participants

Reaction Steps

To a solution of [3-((S)-6-Dimethylamino-4,5,6,7-tetrahydro-benzothiazol-2-ylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester (1.60 g, 3.72 mmol) in DCM (40 mL) and MeOH (0.5 mL) at rt add 4M HCl in dioxane (4.65 mL, 18.6 mmol) and stir the reaction at rt overnight. Dilute the solid suspension with Et2O (300 mL) then filter and wash with Et2O to afford the desired product 3-aminomethyl-N—((S)-6-dimethylamino-4,5,6,7-tetrahydro-benzothiazol-2-yl)-benzamide dihydrochloride as a solid (1.32 g, 3.27 mmol).

Provenance & Evidence