Trifluoroacetic acid → HCID 86667235, compound

Participants

Reaction Steps

Dissolve [3-((S)-6-morpholin-4-yl-4,5,6,7-tetrahydro-benzothiazol-2-ylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester (4.82 g, 10.2 mmol) in DCM (5 mL) and add TFA (trifluoroacetic acid) (20 mL). Stir the mixture at rt for 1 h. LCMS analysis indicates the desired deprotected material. Concentrate to give the desired product 3-aminomethyl-N—((S)-6-morpholin-4-yl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-benzamide as a foam (4.80 g, 9.87 mmol).

Provenance & Evidence