反应详情

To a stirred mixture of 5.5 parts of 4-(methoxymethyl)-1-(1-methylethyl)-N-phenyl-4-piperidinamine in 56 parts of benzene is added dropwise a solution of 13.8 parts of benzeneacetyl chloride in 45 parts of benzene at 26°-32° C. Upon completion, stirring is continued first for one hour at 26°-32° C. and further for 3.60 hours at 38°-55° C. After cooling, the precipitated product is filtered off and converted into the hydrochloride salt in a mixture of 2-propanol and 2-propanone (5:1 by volume). The salt is filtered off and dissolved in absolute ethanol. After standing for 72 hours at room temperature, the precipitated product is filtered off, washed with a small amount of 2-propanone and dried, yielding 1.05 parts of N-[4-(methoxymethyl)-1-(1-methylethyl)-4-piperidinyl]-N-phenylbenzeneacetamide hydrochloride; mp. 249.1° C.

1. temperatureAfter cooling
2. filtrationthe precipitated product is filtered off
3. additionconverted into the hydrochloride salt in a mixture of 2-propanol and 2-propanone (5:1 by volume)
4. filtrationThe salt is filtered off
5. dissolutiondissolved in absolute ethanol
6. waitAfter standing for 72 hours at room temperature
7. filtrationthe precipitated product is filtered off
8. washwashed with a small amount of 2-propanone
9. customdried