Potassium Hydroxide → HCID 131727846, compound

HRID 2367822Notes

Reaction equation

HRID 2367822 reaction equation
C[O:2][C:3]([C:5]1[N:9]=[C:8]([Cl:10])[N:7]([CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:18])([CH3:17])[CH3:16])[N:6]=1)=[O:4].[OH-].[K+:20]>CCO.CCOCC>[K+:20].[Cl:10][C:8]1[N:7]([CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:17])([CH3:18])[CH3:16])[N:6]=[C:5]([C:3]([O-:4])=[O:2])[N:9]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 59128604HCID 59128604, compound

Product 1

HCID 131727846HCID 131727846, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of 4-(4-{[5-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-[1,2,4]triazole-3-carboxylic acid methyl ester (as prepared in the previous step, 227 mg, 0.780 mmol) in EtOH (2 mL), 2 N KOH (0.4 mL, 0.8 mmol) was added. The resulting solution was stirred at RT for 20 min and concentrated in vacuo. The residue obtained was suspended in ether (10 mL) and sonicated for 5 min. The ether was then removed and the resulting residue was dried in vacuo for 4 h to obtain 4-(4-{[5-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-[1,2,4]triazole-3-carboxylic acid potassium salt (223 mg, 91%) which was directly used in the next step without any further purification.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe residue obtained
  3. customsonicated for 5 min
  4. customThe ether was then removed
  5. customthe resulting residue was dried in vacuo for 4 h

Sources & evidence

ORD record
ord-fde29401c6f843a8a803a398619af961
Source dataset
uspto-grants-2014_04
Patent number
US08697716B2

Reaction notes

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