Potassium Hydroxide → potassium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

To a solution of methyl (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (0.16 mL, 1.0 mmol) in MeOH (2 mL), 2 N KOH (0.5 mL, 1 mmol) was added. The resulting solution was stirred at RT for 20 min and concentrated in vacuo. The residue obtained was suspended in ether (10 mL) and sonicated for 5 min. The ether was then removed and the resulting residue was dried in vacuo for 4 h to obtain (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid potassium salt (173 mg, 94%) which was directly used in the next step without purification.

1. concentrationconcentrated in vacuo
2. customThe residue obtained
3. customsonicated for 5 min
4. customThe ether was then removed
5. customthe resulting residue was dried in vacuo for 4 h

ORD record

ord-2f9092d286ba4b389aa7be4d893d0868

Source dataset

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08697716B2