Acetic Anhydride → HCID 15700644, compound

HRID 236788Notes

Reaction equation

HRID 236788 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[N:8]1([C:14]2[C:15]3[CH:28]=[CH:27][CH:26]=[CH:25][C:16]=3[S:17][C:18]=2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1>C(Cl)Cl>[C:5]([N:11]1[CH2:12][CH2:13][N:8]([C:14]2[C:15]3[CH:28]=[CH:27][CH:26]=[CH:25][C:16]=3[S:17][C:18]=2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:9][CH2:10]1)(=[O:7])[CH3:6]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 157006411-(2-Phenyl-1-benzothiophen-3-yl)piperazine

Product 1

HCID 15700644HCID 15700644, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6.15 g (60 mmole) of acetic anhydride are mixed with a solution of 11.8 g (40 mmole) of 3-piperazino-2-phenyl-benzo(b)thiophene in 50 milliliters of methylene chloride and left for 2 hours at ambient temperature. After washing with dilute ammonia the organic phase is dried over Na2SO4 and evaporated: 13.2 g (98% of theory) of colourless needles, mp 167°-169° (CCl4).

Workup

  1. washAfter washing with dilute ammonia the organic phase
  2. dry with materialis dried over Na2SO4
  3. customevaporated

Sources & evidence

ORD record
ord-0e22c63216724c42a8e54d4fe14e7029
Source dataset
uspto-grants-1979_06
Patent number
US04157399

Reaction notes

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