Ammonia → HCID 15700642, compound

HRID 236789Notes

Reaction equation

HRID 236789 reaction equation
[N:1]1([C:7]2[C:8]3[CH:21]=[CH:20][CH:19]=[CH:18][C:9]=3[S:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.C=O.[CH:24](O)=O.N>CO.O>[CH3:24][N:4]1[CH2:3][CH2:2][N:1]([C:7]2[C:8]3[CH:21]=[CH:20][CH:19]=[CH:18][C:9]=3[S:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6][CH2:5]1

Participants

7

Reactant 4

HCID 222AmmoniaHCID 284Formic AcidHCID 712FormaldehydeHCID 157006411-(2-Phenyl-1-benzothiophen-3-yl)piperazine

Product 1

HCID 15700642HCID 15700642, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 7.0 g (24 mmole) of 3-(piperazino)-2-phenyl-benzo(b)thiophene, 3.5 milliliters of formalin at 35% (41 mmole) and 3.5 milliliters of formic acid at 98-100% (92 mmole) is refluxed for 1 hour. After cooling, it is poured into water, made alkaline with ammonia and extracted with CH2Cl2. By evaporating the organic phase dried over K2CO3, 7.2 g (98% of theory) of 3-(4'-methylpiperazino)-2-phenyl-benzo(b)thiophene are obtained: beige crystals, mp 118°-120° (methanol).

Workup

  1. temperatureis refluxed for 1 hour
  2. temperatureAfter cooling
  3. extractionextracted with CH2Cl2
  4. customBy evaporating the organic phase
  5. dry with materialdried over K2CO3, 7.2 g (98% of theory) of 3-(4'-methylpiperazino)-2-phenyl-benzo(b)thiophene
  6. customare obtained

Sources & evidence

ORD record
ord-2d75ac71e3c342b097614e98244cb547
Source dataset
uspto-grants-1979_06
Patent number
US04157399

Reaction notes

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