Potassium Carbonate → HCID 86762364, compound

Participants

Reaction Steps

1-(trimethylsilylethynyl)-4-(4-fluorophenylethynyl)benzene (2.2 g, 7.5 mmol) was dissolved in CH2Cl2 (30 mL) diluted with MeOH (30 mL) and then treated with powdered K2CO3 (2.1 g, 15 mmol) and allowed to stir at ambient temperature for 20 h under N2. The reaction mixture was filtered to remove solids, concentrated, redissolved in CH2Cl2, washed with water (2×), brine, dried over MgSO4, filtered and concentrated to dryness to give 1.43 g (87%) product that was used as is in the next reaction. 1H NMR, (CDCl3) δ: 7.54 (m, 2H), 7.49 (m, 4H); 7.05 (t, J=8.4 Hz, 2H); 3.20 (s, 1H). 13C {1H} NMR (CDCl3): 162.6 (J=250.3 Hz), 133.6 (J=8.0 Hz), 132.1, 131.4, 123.6, 122.0, 119.1 (J=3.6 Hz), 115.7 (J=32.0 Hz), 90.3, 88.6, 83.3, 79.0 ppm.

Provenance & Evidence