Potassium Phosphate, Tribasic → HCID 70202778, compound

Participants

Reaction Conditions

Reaction Steps

3-(4-methoxybenzyloxy)phenylboronic acid (697 mg, 2.7 mmol, 1.5 eq.), methyl 2-bromothiazole-4-carboxylate (400 mg, 1.8 mmol, 1.0 eq.), dicyclohexyl (2′,6′-dimethoxybiphenyl-2-yl) phosphine (74 mg, 0.18 mmol, 10 mol %) and PdCl2 (20 mg, 0.090 mmol, 5 mol %) were dissolved in toluene (6 mL) and added to a solution of K3PO4 (828 mg, 3.6 mmol, 2.0 eq.) in water (0.6 mL). The reaction mixture was heated 20 min at 180° C. in a microwave reactor, allowed to cool, diluted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The crude 23 was used in the next step without purification.

Provenance & Evidence