4-[[2-[[2-[[2-[(2-acetamido-3-hydroxypropanoyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[1-[[1-[[1-[[1-[[2-[[6-amino-1-[2-[(1-amino-3-methyl-1-oxobutan-2-yl)carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid → Czen 002

HRID 2367935Notes

Reaction equation

HRID 2367935 reaction equation
[CH3:1][CH:2]([CH:4]([NH:8][C:9]([CH:11]1[N:15]([C:16]([CH:18]([NH:24][C:25]([CH2:27][NH:28][C:29]([CH:31]([NH:42][C:43]([CH:45]([NH:53][C:54]([CH:56]([NH:64][C:65]([CH:67]([NH:74][C:75]([CH:77]([NH:83][C:84]([CH:86]([NH:91][C:92]([CH:94]([NH:97][C:98]([CH:100]([NH:109][C:110]([CH:112]([NH:115][C:116]([CH3:118])=[O:117])[CH2:113][OH:114])=[O:111])[CH2:101][C:102]2[CH:107]=[CH:106][C:105]([OH:108])=[CH:104][CH:103]=2)=[O:99])[CH2:95][OH:96])=[O:93])[CH2:87][CH2:88][S:89][CH3:90])=[O:85])[CH2:78][CH2:79][C:80]([OH:82])=[O:81])=[O:76])[CH2:68][C:69]2[NH:73][CH:72]=[N:71][CH:70]=2)=[O:66])[CH2:57][C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=2)=[O:55])[CH2:46][CH2:47][CH2:48][NH:49][C:50]([NH2:52])=[NH:51])=[O:44])[CH2:32][C:33]2[C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[NH:35][CH:34]=2)=[O:30])=[O:26])[CH2:19][CH2:20][CH2:21][CH2:22][NH2:23])=[O:17])[CH2:14][CH2:13][CH2:12]1)=[O:10])[C:5]([NH2:7])=[O:6])[CH3:3]>[Na+].[Cl-]>[CH3:3][CH:2]([C@H:4]([NH:8][C:9]([C@H:11]1[N:15]([C:16]([C@@H:18]([NH:24][C:25]([CH2:27][NH:28][C:29]([C@@H:31]([NH:42][C:43]([C@@H:45]([NH:53][C:54]([C@@H:56]([NH:64][C:65]([CH:67]([NH:74][C:75]([C@@H:77]([NH:83][C:84]([C@@H:86]([NH:91][C:92]([C@@H:94]([NH:97][C:98]([C@@H:100]([NH:109][C:110]([C@@H:112]([NH:115][C:116]([CH3:118])=[O:117])[CH2:113][OH:114])=[O:111])[CH2:101][C:102]2[CH:107]=[CH:106][C:105]([OH:108])=[CH:104][CH:103]=2)=[O:99])[CH2:95][OH:96])=[O:93])[CH2:87][CH2:88][S:89][CH3:90])=[O:85])[CH2:78][CH2:79][C:80]([OH:82])=[O:81])=[O:76])[CH2:68][C:69]2[NH:73][CH:72]=[N:71][CH:70]=2)=[O:66])[CH2:57][C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=2)=[O:55])[CH2:46][CH2:47][CH2:48][NH:49][C:50]([NH2:52])=[NH:51])=[O:44])[CH2:32][C:33]2[C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[NH:35][CH:34]=2)=[O:30])=[O:26])[CH2:19][CH2:20][CH2:21][CH2:22][NH2:23])=[O:17])[CH2:14][CH2:13][CH2:12]1)=[O:10])[C:5]([NH2:7])=[O:6])[CH3:1]

Participants

3

Reactant 1

HCID 161326364-[[2-[[2-[[2-[(2-acetamido-3-hydroxypropanoyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[1-[[1-[[1-[[1-[[2-[[6-amino-1-[2-[(1-amino-3-methyl-1-oxobutan-2-yl)carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

Product 1

HCID 16129664Czen 002

Reagents, catalysts & solvents 1

HCID 5234Sodium ChlorideSolvent

Procedure

200 μg α-melanocyte stimulating hormone/kg b.w. in 0.5 ml 150 mM NaCl.

Sources & evidence

ORD record
ord-257e7aa88554435c807dbb3c43dfee4f
Source dataset
uspto-grants-2014_04
Patent number
US08703702B2

Reaction notes

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