Pyridine → HCID 86667165, compound

Participants

Reaction Steps

Compound 2 (625 mg, 1.57 mmol), pyridine (363 μL, 4.69 mmol) and AcCl (272 μL, 3.13 mmol) were dissolved in CH2Cl2 (15 mL) under nitrogen atmosphere at room temperature. After 2 h the mixture was diluted with CH2Cl2. The organic layer was washed (HCl(aq) 5%, sat NaHCO3, brine), dried (MgSO4), filtered and concentrated. No further purification was needed. The reaction yielded 100% of 3. 1H-NMR (CDCl3) 7.45 (m, 6 H), 7.20-7.35 (m, 9 H), 5.14 (t, J=9.49 Hz, 1 H), 2.99-3.10 (m, 2 H), 1.93 (s, 3 H), 1.86 (m, 1 H), 1.50 (m, 2 H), 1.25-1.40 (m, 2 H), 0.80 (m, 1 H).

Provenance & Evidence