HCID 67980106, compound → HCID 67980047, compound

Participants

Reaction Steps

Compound 10 (12.0 mg, 15.6 μmol) was dissolved in NaOMe (0.05 M, 1 mL). After 21 h the mixture was neutralized (Duolite C436) and concentrated. Purification was made by reverse-phase HPLC using a linear gradient of H2O:MECN (100%->0% H2O). The reaction yielded 55% of 15. 1H-NMR (MeOD) 8.38 (d, J=3.53 Hz, 1 H), 8.35 (d, J=3.55 Hz, 1 H), 8.08-8.18 (m, 2 H), 7.33-7.43 (m, 2 H), 7.18-7.33 (m, 4 H), 4.92 (dd, 1 H), 4.76 (d, 9.48 Hz, 1 H), 4.47-4.57 (m, 1 H), 4.28 (dd, J=9.51, 10.55 Hz, 1 H), 4.15 (d, J=2.98 Hz, 1 H), 3.83-3.93 (m, 2 H), 3.76 (dd, J=6.87, 11.35 Hz, 1 H), 3.68 (dd, J=5.19, 11.37 Hz, 1 H), 3.07-3.17 (m, 1 H), 2.28-2.38 (m, 1 H), 2.08-2.25 (m, 2 H), 1.90-2.00 (m, 1 H), 1.60-1.77 (m, 2 H).

Provenance & Evidence