Sodium Hydroxide → HCID 131731332, compound

HRID 2367944Notes

Reaction equation

HRID 2367944 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:35]=[CH:34][C:13]([O:14][CH2:15][CH2:16][O:17][C:18](=[O:33])[CH2:19][CH2:20][C@H:21]([NH:25][C:26](=[O:32])[CH2:27][CH2:28][C:29]([OH:31])=[O:30])[C:22]([OH:24])=[O:23])=[CH:12][CH:11]=2)[C:5]([C:36]#[N:37])=[C:4]([S:38][CH2:39][C:40]2[N:41]=[C:42]([C:45]3[CH:50]=[CH:49][C:48]([Cl:51])=[CH:47][CH:46]=3)[S:43][CH:44]=2)[N:3]=1.[OH-].[Na+:53]>C(#N)C.O>[Na+:53].[Na+:53].[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([O:14][CH2:15][CH2:16][O:17][C:18](=[O:33])[CH2:19][CH2:20][C@H:21]([NH:25][C:26](=[O:32])[CH2:27][CH2:28][C:29]([OH:31])=[O:30])[C:22]([O-:24])=[O:23])=[CH:34][CH:35]=2)[C:5]([C:36]#[N:37])=[C:4]([S:38][CH2:39][C:40]2[N:41]=[C:42]([C:45]3[CH:50]=[CH:49][C:48]([Cl:51])=[CH:47][CH:46]=3)[S:43][CH:44]=2)[N:3]=1.[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([O:14][CH2:15][CH2:16][O:17][C:18](=[O:33])[CH2:19][CH2:20][C@H:21]([NH:25][C:26](=[O:32])[CH2:27][CH2:28][C:29]([OH:31])=[O:30])[C:22]([O-:24])=[O:23])=[CH:34][CH:35]=2)[C:5]([C:36]#[N:37])=[C:4]([S:38][CH2:39][C:40]2[N:41]=[C:42]([C:45]3[CH:50]=[CH:49][C:48]([Cl:51])=[CH:47][CH:46]=3)[S:43][CH:44]=2)[N:3]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 68750135HCID 68750135, compound

Product 1

HCID 131731332HCID 131731332, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

0.5 g (0.667 mmol) of the compound from example 9 is dissolved in 12.5 ml of acetonitrile and 62.5 ml of water, and 13 ml of 0.1 N sodium hydroxide solution are added. After brief stirring, the mixture is lyophilized. After drying under high vacuum, 0.53 g (quant.) of the title compound remain.

Workup

  1. dry with materialAfter drying under high vacuum, 0.53 g (quant.) of the title compound

Sources & evidence

ORD record
ord-78c634b8c0b441eb9996b426b7be8adf
Source dataset
uspto-grants-2014_04
Patent number
US08703696B2

Reaction notes

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