Piperidine → 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[5-(1-piperidinyl)pentyl]-9H-purin-6-amine

Participants

Reaction Conditions

Reaction Steps

9-(5-Chloropentyl)-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine (for example, as prepared for Intermediate 8) (80 mg, 0.225 mmol), triethylamine (0.031 mL, 0.225 mmol) and piperidine (0.045 mL, 0.45 mmol) were suspended in DMF (3 mL) and the mixture heated to 70° C. for 18 hours. The solvent was removed and the residue partitioned between dichloromethane (4 mL) and saturated sodium bicarbonate (4 mL). The aqueous phase was re-extracted with further dichloromethane and the combined organic extracts were concentrated and the residue dissolved in 1:1 methanol:DMSO (1 mL) and purified by MDAP (Method A). The product-containing fractions were combined and evaporated under a stream of nitrogen to give the title compound (47.2 mg).

Provenance & Evidence