HCID 66632553, compound → HCID 58044466, compound

Participants

Reaction Conditions

Reaction Steps

2-(3-oxo-6-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-2 (3H)-yl)-N-(2-oxopropyl)acetamide was dissolved in POCl3 (3 mL) in a 50 mL round bottomed flask. The mixture was heated at 70-90° C. for 2 h and then 100° C. for 15 h. After removal of POCl3 under a reduced pressure, obtained residue was quenched with sat. NaHCO3 aq. solution (30 mL). The whole was extracted with EtOAc (30 mL×3). Combined organic layers were washed with brine (30 mL) and dried over Na2SO4. The solvent was removed under a reduced pressure to give compound 172 as pink crystals, 30.3 mg, 0.0756 mmol, >99%). LCMS (EI: 70 eV) 397 (M++Na), 375 (M++1).

Provenance & Evidence