HCID 70655759, compound → HCID 70655771, compound

HRID 2368039Notes

Reaction equation

HRID 2368039 reaction equation
[CH3:1][C:2]1([CH3:18])[CH2:7][CH2:6][C:5]([C:8]2[C:9]3[N:10]([N:14]=[C:15]([NH2:17])[N:16]=3)[CH:11]=[CH:12][CH:13]=2)=[CH:4][CH2:3]1>CO.[Pd]>[CH3:1][C:2]1([CH3:18])[CH2:3][CH2:4][CH:5]([C:8]2[C:9]3[N:10]([N:14]=[C:15]([NH2:17])[N:16]=3)[CH:11]=[CH:12][CH:13]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 1

HCID 70655759HCID 70655759, compound

Product 1

HCID 70655771HCID 70655771, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

To a solution 8-(4,4-dimethyl-cyclohex-1-enyl)-[1,2,4]triazolo[1,5-a]pyridine-2-yl-amine (30 mg, 0.124 mmol) in methanol (4 mL) was added 10% Pd/C (30 mg), and the reaction mixture was allowed to stir under hydrogen balloon atmosphere at 25° C. for 2 hours. The reaction mixture was filtered through a bed of celite, and the filtrate was evaporated off in vacuo to get the title compound (30 mg, 99%) as a white solid which was used in next step without further purification. MS ISP (m/e): 245.0 (100) [(M+H)+].

Workup

  1. filtrationThe reaction mixture was filtered through a bed of celite
  2. customthe filtrate was evaporated off in vacuo

Sources & evidence

ORD record
ord-1b4e3d33f65f4e15854969de6ffcb6de
Source dataset
uspto-grants-2014_04
Patent number
US08703763B2

Reaction notes

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