Fluoxetine hydrochloride → Venlafaxine

HRID 2368043Notes

Reaction equation

HRID 2368043 reaction equation
[CH3:1][N:2]([CH2:4]CCC1(C2C=CC(F)=CC=2)OCC2C=C(C#N)C=CC1=2)[CH3:3].Br.CNCC[CH:30]([O:37][C:38]1[CH:39]=[CH:40][C:41]([C:44](F)(F)F)=[CH:42][CH:43]=1)C1C=CC=CC=1.Cl.COCCCC/C(/C1C=CC(C(F)(F)F)=CC=1)=N\OCCN.C(/C(O)=O)=C/C(O)=O.C1C([C@H]2[C@H](CO[C:93]3[CH:94]=[CH:95][C:96]4OC[O:99][C:97]=4[CH:98]=3)CNCC2)=CC=C(F)C=1.Cl>>[CH3:1][N:2]([CH2:4][CH:44]([C:97]1([OH:99])[CH2:98][CH2:93][CH2:94][CH2:95][CH2:96]1)[C:41]1[CH:40]=[CH:39][C:38]([O:37][CH3:30])=[CH:43][CH:42]=1)[CH3:3]

Participants

5

Reactant 4

HCID 62857Fluoxetine hydrochlorideHCID 62878Paroxetine HydrochlorideHCID 77995Citalopram HydrobromideHCID 9560989Fluvoxamine maleate

Product 1

HCID 5656Venlafaxine

Procedure

pharmaceutically acceptable salts thereof (for example: citalopram hydrobromide CAS #59729-32-7; fluoxetine hydrochloride CAS #59333-67-4; fluvoxamine maleate CAS #61718-82-9; paroxetine hydrochloride CAS #78246-49-8; and sertraline hydrochloride 79559-97-0).

Sources & evidence

ORD record
ord-bfb64e3a1d9b4d12b959f82bb7da8c43
Source dataset
uspto-grants-2014_04
Patent number
US08703764B2

Reaction notes

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