Water → HCID 57791809, compound

Participants

Reaction Steps

To a suspension of tert-butyl 4-hydroxypiperidine-1-carboxylate (5.00 g) and tert-butoxy potassium (5.57 g) in THF (124 mL) was added 4-(chloroacetyl)morpholine (4.84 mL), and the mixture was stirred at room temperature overnight. Distilled water was added to the reaction mixture, the mixture was extracted with ethyl acetate, and the solution was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure, and the obtained solid was washed with hexane-ethyl acetate to give the title compound (4.74 g).

Provenance & Evidence