Ethyl diazoacetate → HCID 57517486, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 1-(diphenylmethyl)azetidin-3-ol (12 g) and rhodium(II) acetate dimer (1.1 g) in toluene (150 mL) was added dropwise ethyl diazoacetate (6.28 g) at 80° C. The mixture was stirred at 80° C. for 3 hr. Furthermore, ethyl diazoacetate (6.28 g) was added dropwise at 80° C., and the mixture was stirred at 80° C. for 3 hr. The mixture was allowed to cool, and filtered through a silica gel short column. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (9.0 g).

Provenance & Evidence