Phosphorus pentachloride → HCID 21315996, compound

HRID 236811Notes

Reaction equation

HRID 236811 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][C:10]3=[CH:12][S:13][CH:14]=[C:9]3[C:8](=O)[NH:7][C:6]=2[CH:16]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:18]>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][C:10]3=[CH:12][S:13][CH:14]=[C:9]3[C:8]([Cl:18])=[N:7][C:6]=2[CH:16]=1

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 12703385HCID 12703385, compound

Product 1

HCID 21315996HCID 21315996, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A 2.13 g. portion of 7-bromo-thieno[3,4-b][1,5]benzoxazepin-10(9H)-one (Example 9) and 1.5 g. of phosphorus pentachloride in 40 ml. of dry toluene are reacted as described in Example 9, giving 7-bromo-10-chloro-thieno[3,4-b][1,5]benzoxazepine which is further reacted with N-methylpiperazine in 15 ml. of dry toluene giving the base compound as a foam which is then converted to the hemifumarate, m.p. 196°-197° C.

Sources & evidence

ORD record
ord-0e576df42057403dbd67b04a77b54bd7
Source dataset
uspto-grants-1979_06
Patent number
US04157444

Reaction notes

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